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Article

Germline deletion of Cdyl causes teratozoospermia and progressive infertility in male mice

8 Mar 2019

Abstract excerpt

Abstract Chromodomain Y(CDY) is one of the candidate genes for male dyszoospermia related to Y chromosome microdeletion (YCM). However, the function of CDY in regulating spermatogenesis has not been completely determined. The mouseCdyl (CDY-like)gene is the homolog of humanCDY. In the present study, we generated a germline conditional knockout (cKO) model of mouseCdyl. Significantly, theCdylcKOmale mice suffered...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 30850578
DOI: 10.1038/s41419-019-1455-y

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