Article
Chromodomain Protein CDYL Acts as a Crotonyl-CoA Hydratase to Regulate Histone Crotonylation and Spermatogenesis.
Molecular cell - 7 Sept 2017
Liu Shumeng, Yu Huajing, Liu Yongqing, Liu Xinhua, Zhang Yu, Bu Chen, Yuan Shuai, Chen Zhe, Xie Guojia, Li Wanjin, Xu Bosen, Yang Jianguo, He Lin, Jin Tong, Xiong Yundong, Sun Luyang, Liu Xiaohui, Han Chunsheng, Cheng Zhongyi, Liang Jing, Shang Yongfeng
Abstract excerpt
Lysine crotonylation (Kcr) is a newly identified histone modification that is associated with active transcription in mammalian cells. Here we report that the chromodomain Y-like transcription corepressor CDYL negatively regulates histone Kcr by acting as a crotonyl-CoA hydratase to convert crotonyl-CoA to β-hydroxybutyryl-CoA. We showed that the negative regulation of histone Kcr by CDYL is intrinsically linked...
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