Systematic identification of Y-chromosome gene functions in mouse spermatogenesis

Abstract excerpt

The mammalian Y chromosome is essential for male fertility, but how individual Y genes regulate spermatogenesis is poorly understood. To resolve this question, we generate a deletion series of the mouse Y chromosome, creating thirteen Y-deletant mouse models and conducting exhaustive reproductive phenotyping. Eight Y genes, including several that are deeply conserved and exhibit testis-specific expression, are dis...

Topics

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• Spermatogenesis
• Animal Genetics and Reproduction
• Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
• Genetic Association Studies
• Infertility, Male
• Mice
• Mutation
• Sperm and Testicular Function

Identifiers and source

Literature Corpus work

7571ec16-6271-573a-aaf5-e2ff8d100e8f

DOI

10.1101/2024.07.18.604063