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Article

AZFa candidate gene UTY and its X homologue UTX are expressed in human germ cells

11 May 2021

Abstract excerpt

The Ubiquitous Transcribed Y ( UTY a.k.a. KDM6C ) AZFa candidate gene on the human Y chromosome and its paralog on the X chromosome, UTX (a.k.a. KDM6A ), encode a histone lysine demethylase removing chromatin H3K27 methylation marks at genes transcriptional start sites for activation. Both proteins harbour the conserved Jumonji C (JmjC) domain, functional in chromatin metabolism, and an extended N-terminal...

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PMID: 35128450
DOI: 10.1530/raf-20-0049

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