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Article

GCN5-mediated transcriptional control of the metabolic coactivator PGC-1beta through lysine acetylation.

The Journal of biological chemistry - 24 Jul 2009

Kelly Timothy J, Lerin Carles, Haas Wilhelm, Gygi Steven P, Puigserver Pere

Abstract excerpt

Changes in expression levels of genes encoding for proteins that control metabolic pathways are essential to maintain nutrient and energy homeostasis in individual cells as well as in organisms. An important regulated step in this process is accomplished through covalent chemical modifications of proteins that form complexes with the chromatin of gene promoters. The peroxisome proliferators gamma co-activator 1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19491097
DOI: 10.1074/jbc.M109.015164
PMCID: PMC2740420

Genes

PGC
SIRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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