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Article

ADAR1 Isoforms Regulate Let-7d Processing in Idiopathic Pulmonary Fibrosis

12 Aug 2022

Abstract excerpt

Double-stranded RNA adenosine deaminase 1 (ADAR1) is significantly down-regulated in fibroblasts derived from Idiopathic Pulmonary Fibrosis (IPF) patients, and its overexpression restored levels of miRNA-21, PELI1, and SPRY2. There are two ADAR1 isoforms in humans, ADAR1-p110 and ADAR1-p150, generated by an alternative promoter. Let-7d is considered an essential microRNA in Pulmonary Fibrosis (PF). In silico...

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PMID: 36012303
DOI: 10.3390/ijms23169028

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