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Article

Prognostic impact of ATM mutations in patients with metastatic colorectal cancer

27 Feb 2019

Abstract excerpt

Tumors bearing homologous recombination deficiency are extremely sensitive to DNA double strand breaks induced by several chemotherapeutic agents. ATM gene, encoding a protein involved in DNA damage response, is frequently mutated in colorectal cancer (CRC), but its potential role as predictive and prognostic biomarker has not been fully investigated. We carried out a multicenter effort aimed at defining the...

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PMID: 30814645
DOI: 10.1038/s41598-019-39525-3

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