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In Silico-Analysis of the Multi-Omics Data Identified the Ataxia Telangiectasia Mutated Gene as a Potential Biomarker of Breast Invasive Carcinoma.

Genetic testing and molecular biomarkers - 1 Apr 2021

Karamat Uzma, Ejaz Samina, Hameed Yasir

Abstract excerpt

Background: The elevated global burden of the breast invasive carcinoma (BRIC) and lack of appropriate biomarkers for its early detection and treatment requires extensive investigation to enhance understanding regarding BRIC associated molecular alterations. Ataxia telangiectasia mutated (ATM) is a multifunctional tumor suppressor gene, which participates in the DNA damage response pathway and cellular checkpoint...

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PMID: 33877897
DOI: 10.1089/gtmb.2020.0249

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