Article
Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1.
Cancer research - 15 Nov 2010
Seltzer Meghan J, Bennett Bryson D, Joshi Avadhut D, Gao Ping, Thomas Ajit G, Ferraris Dana V, Tsukamoto Takashi, Rojas Camilo J, Slusher Barbara S, Rabinowitz Joshua D, Dang Chi V, Riggins Gregory J
Abstract excerpt
Mutation at the R132 residue of isocitrate dehydrogenase 1 (IDH1), frequently found in gliomas and acute myelogenous leukemia, creates a neoenzyme that produces 2-hydroxyglutarate (2-HG) from α-ketoglutarate (α-KG). We sought to therapeutically exploit this neoreaction in mutant IDH1 cells that require α-KG derived from glutamine. Glutamine is converted to glutamate by glutaminase and further metabolized to α-KG....
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