Article

Inferring Bladder Cancer Evolution from Mucosal Field Effects by Whole-Organ Spatial Mutational, Proteomic, and Metabolomic Mapping

2024-04-10

Abstract excerpt

<title>Abstract</title> <p>Multi-platform mutational, proteomic, and metabolomic spatial mapping was used on the whole-organ scale to identify the molecular evolution of bladder cancer from mucosal field effects. We identified complex proteomic and metabolomic dysregulations in microscopically normal areas of bladder mucosa adjacent to dysplasia and carcinoma <italic>in situ</italic>. The mutational landscape dev...

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Literature Corpus work: 8ea9b0fa-0a27-545b-8490-a1ff34819a19
DOI: 10.21203/rs.3.rs-3994376/v1

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