Article
Plasma urate and risk of Parkinson's disease: A mendelian randomization study.
Annals of neurology - 1 Aug 2018
Kobylecki Camilla J, Nordestgaard Børge G, Afzal Shoaib
Abstract excerpt
OBJECTIVE: Urate is a potent antioxidant, and high plasma urate has been associated with lower incidence of Parkinson's disease (PD) in epidemiological studies. We tested the hypothesis that high concentrations of plasma urate are associated with low incidence of PD. METHODS: We performed observational and genetic analyses using plasma urate and the urate SLC2A9 rs7442295 and ABCG2 rs2231142 genotype in >102,000...
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