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Metformin Mediates Protection against Legionella Pneumonia through Activation of AMPK and Mitochondrial Reactive Oxygen Species

15 Dec 2017

Abstract excerpt

Abstract In Legionella pneumophila infection, macrophages play a critical role in the host defense response. Metformin, an oral drug for type 2 diabetes, is attracting attention as a new supportive therapy against a variety of diseases, such as cancer and infectious diseases. The novel mechanisms for metformin actions include modulation of the effector functions of macrophages and other host immune cells. In this...

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Share to Autophagy in Disease and Therapy
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PMID: 29246951
DOI: 10.4049/jimmunol.1700474

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