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Article

Pharmacological targets of metabolism in disease: Opportunities from macrophages.

Pharmacology & therapeutics - 1 Jun 2020

Castegna Alessandra, Gissi Rosanna, Menga Alessio, Montopoli Monica, Favia Maria, Viola Antonella, Canton Marcella

Abstract excerpt

From advances in the knowledge of the immune system, it is emerging that the specialized functions displayed by macrophages during the course of an immune response are supported by specific and dynamically-connected metabolic programs. The study of immunometabolism is demonstrating that metabolic adaptations play a critical role in modulating inflammation and, conversely, inflammation deeply influences the...

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PMID: 32151665
DOI: 10.1016/j.pharmthera.2020.107521

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