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Article

Overexpression of SIRT4 inhibits the proliferation of gastric cancer cells through cell cycle arrest

28 Dec 2018

Abstract excerpt

The sirtuins (SIRTs) are a family of nicotinamide-adenine dinucleotide (NAD)+‑dependent protein deacetylases. SIRT4 is a mitochondrial NAD+‑dependent adenosine diphsophate‑ribosyltransferase. Recent studies demonstrated that SIRT4 can regulate glutamine metabolism and thus act as a tumor suppressor. However, the association of SIRT4 with gastric cancer remains unknown. The present study investigated the potential...

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Identifiers

PMID: 30745932
DOI: 10.3892/ol.2018.9877

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