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SIRT1 is a regulator of autophagy: Implications in gastric cancer progression and treatment

3 Jun 2015

Abstract excerpt

Silent mating type information regulation 1 (SIRT1) is implicated in tumorigenesis through its effect on autophagy. In gastric cancer (GC), SIRT1 is a marker for prognosis and is involved in cell invasion, proliferation, epithelial-mesenchymal transition (EMT) and drug resistance. Autophagy can function as a cell-survival mechanism or lead to cell death during the genesis and treatment of GC. This functionality...

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PMID: 26049033
DOI: 10.1016/j.febslet.2015.05.042

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