Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NANOG reprograms prostate cancer cells to castration resistance via dynamically repressing and engaging the AR/FOXA1 signaling axis

15 Nov 2016

Abstract excerpt

The pluripotency transcription factor NANOG has been implicated in tumor development, and NANOG-expressing cancer cells manifest stem cell properties that sustain tumor homeostasis, mediate therapy resistance and fuel tumor progression. However, how NANOG converges on somatic circuitry to trigger oncogenic reprogramming remains obscure. We previously reported that inducible NANOG expression propels the emergence...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to FOXO transcription factor regulation
Share to Prostate Cancer Treatment and Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27867534
DOI: 10.1038/celldisc.2016.41

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NANOG reprograms prostate cancer cells to castration resistance via dynamically repressing and engaging the AR/FOXA1 signaling axisPMID 27867534Read ↗

The pluripotency factor Nanog is directly upregulated by the Androgen Receptor in prostate cancer cellsSemantic proximity Read ↗

Androgen Deprivation Induces Transcriptional Reprogramming in Prostate Cancer Cells to Develop Stem Cell-Like CharacteristicsSemantic proximity Read ↗

NANOG promotes cancer stem cell characteristics and prostate cancer resistance to androgen deprivation.Semantic proximity Read ↗

Unlocking the Role of OCT4 in Cancer Lineage Plasticity: A Cross-Cancer Perspective with an Emphasis on Prostate CancerSemantic proximity Read ↗

Prostate cancer stem cell dynamics in the evolution of drug resistanceSemantic proximity Read ↗

Functional Evidence that the Self-Renewal Gene <i>NANOG</i> Regulates Human Tumor DevelopmentSemantic proximity Read ↗

Drug-induced epigenomic plasticity reprograms circadian rhythm regulation to drive prostate cancer towards androgen-independenceSemantic proximity Read ↗

Cellular cartography reveals mouse prostate organization and determinants of castration resistanceSemantic proximity Read ↗

NANOG helps cancer cells escape NK cell attack by downregulating ICAM1 during tumorigenesisSemantic proximity Read ↗

Concise Review: NANOG in Cancer Stem Cells and Tumor Development: An Update and Outstanding QuestionsSemantic proximity Read ↗

Exosome-delivered NR2F1-AS1 and NR2F1 drive phenotypic transition from dormancy to proliferation in treatment-resistant prostate cancer via stabilizing hormonal receptors.Semantic proximity Read ↗

The induction of core pluripotency master regulators in cancers defines poor clinical outcomes and treatment resistanceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.