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Article

Molecular heterogeneity and early metastatic clone selection in testicular germ cell cancer development

1 Feb 2019

Abstract excerpt

BACKGROUND: Testicular germ cell cancer (TGCC), being the most frequent malignancy in young Caucasian males, is initiated from an embryonic germ cell. This study determines intratumour heterogeneity to unravel tumour progression from initiation until metastasis. METHODS: In total, 42 purified samples of four treatment-resistant nonseminomatous (NS) TGCC were investigated, including the precursor germ cell...

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PMID: 30739914
DOI: 10.1038/s41416-019-0381-1

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