Article
Intratumoral heterogeneity and chemoresistance in nonseminomatous germ cell tumor of the testis.
Oncotarget - 27 Dec 2016
Bilen Mehmet Asim, Hess Kenneth R, Campbell Matthew T, Wang Jennifer, Broaddus Russell R, Karam Jose A, Ward John F, Wood Christopher G, Choi Seungtaek L, Rao Priya, Zhang Miao, Naing Aung, General Rosale, Cauley Diana H, Lin Sue-Hwa, Logothetis Christopher J, Pisters Louis L, Tu Shi-Ming
Abstract excerpt
BACKGROUND: Nonseminomatous germ cell tumor of the testis (NSGCT) is largely curable. However, a small group of patients develop refractory disease. We investigated the hypothesis that intratumoral heterogeneity contributes to the emergence of chemoresistance and the development of refractory tumor subtypes. RESULTS: Our institution's records for January 2000 through December 2010 included 275 patients whose...
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