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Article

Intratumoral heterogeneity: Role of differentiation in a potentially lethal phenotype of testicular cancer.

Cancer - 15 Jun 2016

Tu Shi-Ming, Bilen Mehmet Asim, Hess Kenneth R, Broaddus Russell R, Kopetz Scott, Wei Chongjuan, Pagliaro Lance C, Karam Jose A, Ward John F, Wood Christopher G, Rao Priya, Tu Zachary H, General Rosale, Chen Adrienne H, Nieto Yago L, Yeung Sai-Ching J, Lin Sue-Hwa, Logothetis Christopher J, Pisters Louis L

Abstract excerpt

BACKGROUND: Intratumoral heterogeneity presents a major obstacle to the widespread implementation of precision medicine. The authors assessed the origin of intratumoral heterogeneity in nonseminomatous germ cell tumor of the testis (NSGCT) and identified distinct tumor subtypes and a potentially lethal phenotype. METHODS: In this retrospective study, all consecutive patients who had been diagnosed with an NSGCT...

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Share to Cell Differentiation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Multivariate Analysis

Share to Neoplasms, Germ Cell and Embryonal

Share to Neoplastic Stem Cells

Share to Proportional Hazards Models

Share to Testicular Neoplasms

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Source

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Identifiers

PMID: 27018785
DOI: 10.1002/cncr.29996
PMCID: PMC5071733

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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