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Clonal diversification and histogenesis of malignant germ cell tumours

11 Aug 2022

Abstract excerpt

Germ cell tumours (GCTs) are a collection of benign and malignant neoplasms derived from primordial germ cells. They are uniquely able to recapitulate embryonic and extraembryonic tissues, which carries prognostic and therapeutic significance. The developmental pathways underpinning GCT initiation and histogenesis are incompletely understood. Here, we study the relationship of histogenesis and clonal...

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PMID: 35953478
DOI: 10.1038/s41467-022-31375-4

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