Article
On the role of Staphylococcus aureus sortase and sortase-catalyzed surface protein anchoring in murine septic arthritis.
The Journal of infectious diseases - 15 May 2002
Jonsson Ing-Marie, Mazmanian Sarkis K, Schneewind Olaf, Verdrengh Margareta, Bremell Tomas, Tarkowski Andrzej
Abstract excerpt
Anchoring of Staphylococcus aureus surface protein to the cell wall is catalyzed by sortase, a transpeptidase. The contribution of staphylococcal surface proteins to establishment of infection was examined using a murine septic arthritis model. Intravenous inoculation of mice with the sortase-deficient mutant S. aureus strain SMK3 did not result in weight loss or severe septic arthritis, in contrast to the parent...
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