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Article

Experimental prostate epithelial morphogenesis in response to stroma and three-dimensional matrigel culture.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Dec 2001

Lang S H, Stark M, Collins A, Paul A B, Stower M J, Maitland N J

Abstract excerpt

To reproduce the structural and functional differentiation of human prostatic acini in vivo, prostatic epithelial and stromal cells derived from human primary cultures were cocultured in Matrigel. In the absence of stroma and serum, epithelial spheroids composed of solid masses of stratified and cuboidal cells formed. Outer cells of the spheroid expressed cytokeratins 1, 5, 10, and 14, whereas the inner cells...

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PMID: 11751458

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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