Article

Epigenetic analysis of Paget’s disease of bone identifies differentially methylated loci that predict disease status

2021-01-05

Abstract excerpt

Paget’s Disease of Bone (PDB) is characterized by focal increases in disorganized bone remodeling. This study aims to characterize PDB associated changes in DNA methylation profiles in patients’ blood. Meta-analysis of data from the discovery and replication set, comprising of 116 PDB cases and 130 controls, revealed significant differences in DNA methylation at 14 CpG sites, 4 CpG islands, and 6 gene-body regions...

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Literature Corpus work: 3700bcee-be92-5d31-842b-2140cb7e15a5
DOI: 10.1101/2021.01.04.425216

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