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The developmental stage of the hematopoietic niche regulates lineage in MLL-rearranged leukemia

6 Feb 2019

Abstract excerpt

Leukemia phenotypes vary with age of onset. Delineating mechanisms of age specificity in leukemia could improve disease models and uncover new therapeutic approaches. Here, we used heterochronic transplantation of leukemia driven by MLL/KMT2A translocations to investigate the contribution of the age of the hematopoietic microenvironment to age-specific leukemia phenotypes. When driven by MLL-AF9, leukemia cells...

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PMID: 30728174
DOI: 10.1084/jem.20181765

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