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Article

MicroRNA-155 coordinates the immunological landscape within murine melanoma and correlates with immunity in human cancers

5 Feb 2019

Abstract excerpt

miR-155 has recently emerged as an important promoter of antitumor immunity through its functions in T lymphocytes. However, the impact of T cell-expressed miR-155 on immune cell dynamics in solid tumors remains unclear. In the present study, we used single-cell RNA sequencing to define the CD45+ immune cell populations at different time points within B16F10 murine melanoma tumors growing in either wild-type or...

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PMID: 30721153
DOI: 10.1172/jci.insight.126543

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