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Spatial proteomics reveals sirtuin 1 to be a determinant of T-cell infiltration in human melanoma

12 Dec 2024

Abstract excerpt

BACKGROUND: The tumour microenvironment significantly influences the clinical response of patients to therapeutic immune checkpoint inhibition (ICI), but a comprehensive understanding of the underlying immune-regulatory proteome is still lacking. OBJECTIVES: To decipher targetable biologic processes that determine tumour-infiltrating lymphocytes (TiLs) as a cellular equivalent of clinical response to ICI....

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PMID: 39739311
DOI: 10.1093/bjd/ljae433

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