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Neoantigen screening identifies broad TP53 mutant immunogenicity in patients with epithelial cancers

4 Feb 2019

Abstract excerpt

The adoptive cell transfer of select tumor-infiltrating lymphocytes (TILs) for personalized immunotherapy can mediate long-term objective tumor regressions in patients with metastatic melanoma, bile duct, cervix, colon, and breast cancers (1–5). These clinical responses are likely mediated by recognition of mutated gene products termed neoantigens because they are absent in normal tissues. Intratumoral T cell...

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PMID: 30714987
DOI: 10.1172/jci123791

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