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Article

T-cell Responses to TP53 "Hotspot" Mutations and Unique Neoantigens Expressed by Human Ovarian Cancers.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Nov 2018

Deniger Drew C, Pasetto Anna, Robbins Paul F, Gartner Jared J, Prickett Todd D, Paria Biman C, Malekzadeh Parisa, Jia Li, Yossef Rami, Langhan Michelle M, Wunderlich John R, Danforth David N, Somerville Robert P T, Rosenberg Steven A

Abstract excerpt

Purpose: This was a study prospectively evaluating intratumoral T-cell responses to autologous somatic mutated neoepitopes expressed by human metastatic ovarian cancers.Patients and Methods: Tumor-infiltrating lymphocytes (TIL) were expanded from resected ovarian cancer metastases, which were analyzed by whole-exome and transcriptome sequencing to identify autologous somatic mutations. All mutated neoepitopes,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29853601
DOI: 10.1158/1078-0432.CCR-18-0573
PMCID: PMC6239943

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