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Article

Isolation and characterization of patient-derived CNS metastasis-associated stromal cell lines

30 Jan 2019

Abstract excerpt

The functional role of human derived stromal cells in the tumor microenviornment of CNS metastases (CM) remain understudied. The purpose of the current study was to isolate and characterize stromal cells of the tumor microenvironment in CM. Four different patient-derived cell lines (PDCs) of stromal and one PDC of tumorigenic origin were generated from breast or lung CM. PDCs were analyzed by DNA/RNA sequencing,...

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PMID: 30700832
DOI: 10.1038/s41388-019-0680-2

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