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Article

Impaired non-homologous end joining in human primary alveolar type II cells in emphysema

29 Jan 2019

Abstract excerpt

Emphysema is characterized by alveolar wall destruction induced mainly by cigarette smoke. Oxidative damage of DNA may contribute to the pathophysiology of this disease. We studied the impairment of the non-homologous end joining (NHEJ) repair pathway and DNA damage in alveolar type II (ATII) cells and emphysema development. We isolated primary ATII cells from control smokers, nonsmokers, and patients with...

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PMID: 30696938
DOI: 10.1038/s41598-018-37000-z

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