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Mitochondrial dysfunction in human primary alveolar type II cells in emphysema

1 Aug 2019

Abstract excerpt

BACKGROUND: Cigarette smoke is the main risk factor of pulmonary emphysema development, which is characterized by alveolar wall destruction. Mitochondria are important for alveolar type II (ATII) cell metabolism due to ATP generation. METHODS: We isolated ATII cells from control non-smoker and smoker organ donors, and after lung transplant of patients with emphysema to determine mitochondrial function, dynamics...

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PMID: 31383554
DOI: 10.1016/j.ebiom.2019.07.063

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