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Article

STAT3 Activity and Function in Cancer: Modulation by STAT5 and miR-146b

23 Apr 2014

Abstract excerpt

The transcription factor STAT3 regulates genes that control critical cellular processes such as proliferation, survival, pluripotency, and motility. Thus, under physiological conditions, the transcriptional function of STAT3 is tightly regulated as one part of a complex signaling matrix. When these processes are subverted through mutation or epigenetic events, STAT3 becomes highly active and drives elevated...

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PMID: 24762632
DOI: 10.3390/cancers6020958

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