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Article

Fc Sialylation Prolongs Serum Half-Life of Therapeutic Antibodies

25 Jan 2019

Abstract excerpt

Abstract The long serum t1/2 of IgGs is ensured by their interaction with the neonatal Fc receptor (FcRn), which salvages IgG from intracellular degradation. Fc glycosylation is thought not to influence FcRn binding and IgG longevity in vivo. In this article, we demonstrate that hypersialylation of asparagine 297 (N297) enhances IgG serum persistence. This polarized glycosylation is achieved using a novel Fc...

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PMID: 30683704
DOI: 10.4049/jimmunol.1800896

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