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Article

CD8+ T cells specific for conserved, cross-reactive Gag epitopes with strong ability to suppress HIV-1 replication.

Retrovirology - 3 Jul 2018

Murakoshi Hayato, Zou Chengcheng, Kuse Nozomi, Akahoshi Tomohiro, Chikata Takayuki, Gatanaga Hiroyuki, Oka Shinichi, Hanke Tomáš, Takiguchi Masafumi

Abstract excerpt

BACKGROUND: Development of AIDS vaccines for effective prevention of circulating HIV-1 is required, but no trial has demonstrated definitive effects on the prevention. Several recent T-cell vaccine trials showed no protection against HIV-1 acquisition although the vaccines induced HIV-1-specific T-cell responses, suggesting that the vaccine-induced T cells have insufficient capacities to suppress HIV-1...

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Share to CD8-Positive T-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epitope Mapping

Share to Epitopes, T-Lymphocyte

Share to gag Gene Products, Human Immunodeficiency Virus

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Share to T-Cell Antigen Receptor Specificity

Source

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Identifiers

PMID: 29970102
DOI: 10.1186/s12977-018-0429-y
PMCID: PMC6029025

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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