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Article

Gain-of-Function Alleles in Caenorhabditis elegans Nuclear Hormone Receptor nhr-49 Are Functionally Distinct.

PloS one - 1 Jan 2016

Lee Kayoung, Goh Grace Ying Shyen, Wong Marcus Andrew, Klassen Tara Leah, Taubert Stefan

Abstract excerpt

Nuclear hormone receptors (NHRs) are transcription factors that regulate numerous physiological and developmental processes and represent important drug targets. NHR-49, an ortholog of Hepatocyte Nuclear Factor 4 (HNF4), has emerged as a key regulator of lipid metabolism and life span in the nematode worm Caenorhabditis elegans. However, many aspects of NHR-49 function remain poorly understood, including whether...

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PMID: 27618178
DOI: 10.1371/journal.pone.0162708
PMCID: PMC5019492

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