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Article

Universal screening of both endometrial and colon cancers increases the detection of Lynch syndrome.

Cancer - 1 Aug 2018

Adar Tomer, Rodgers Linda H, Shannon Kristen M, Yoshida Makoto, Ma Tianle, Mattia Anthony, Lauwers Gregory Y, Iafrate Anthony J, Hartford Nicole M, Oliva Esther, Chung Daniel C

Abstract excerpt

BACKGROUND: Lynch syndrome (LS) is the most common hereditary cause of colorectal cancer (CRC) and endometrial cancer (EC). Screening of all CRCs for LS is currently recommended, but screening of ECs is inconsistent. The objective of this study was to determine the added value of screening both CRC and EC tumors in the same population. METHODS: A prospective, immunohistochemistry (IHC)-based screening program for...

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Topics

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Share to Colonic Neoplasms
Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Early Detection of Cancer

Share to Endometrial Neoplasms

Share to Gene Expression Regulation, Neoplastic

Share to Mismatch Repair Endonuclease PMS2

Share to MutL Protein Homolog 1

Share to MutS Homolog 2 Protein

Source

Identifiers

PMID: 29750335
DOI: 10.1002/cncr.31534

Genes

MLH1
BRAF
MSH2
MSH6
PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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