Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A state-wide population-based program for detection of lynch syndrome based upon immunohistochemical and molecular testing of colorectal tumours.

Familial cancer - 1 Mar 2012

Schofield Lyn, Grieu Fabienne, Goldblatt Jack, Amanuel Benhur, Iacopetta Barry

Abstract excerpt

We have previously established in a large retrospective study that testing for microsatellite instability (MSI) in colorectal cancer (CRC) from patients aged <60 years was an effective first screen to identify individuals with Lynch syndrome (LS). From these findings, MSI and/or immunohistochemical (IHC) screening was recommended for all newly diagnosed CRC patients aged <60 years in Western Australia, regardless...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colorectal Neoplasms, Hereditary Nonpolyposis
Share to DNA Mismatch Repair

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Follow-Up Studies

Share to Immunoenzyme Techniques

Share to Microsatellite Instability

Share to Prognosis

Share to Proto-Oncogene Proteins B-raf

Share to Western Australia

Source

Identifiers

PMID: 22120844
DOI: 10.1007/s10689-011-9494-2

Genes

BRAF
MLH1
MSH2
MSH6
PMS2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A state-wide population-based program for detection of lynch syndrome based upon immunohistochemical and molecular testing of colorectal tumours.PMID 22120844Read ↗

Population‐based screening for Lynch syndrome in Western AustraliaSemantic proximity Read ↗

Population‐based detection of Lynch syndrome in young colorectal cancer patients using microsatellite instability as the initial testSemantic proximity Read ↗

BRAFV600E immunohistochemistry facilitates universal screening of colorectal cancers for Lynch syndrome.Semantic proximity Read ↗

Systematic immunohistochemical screening for Lynch syndrome in colorectal cancer: a single centre experience of 486 patients.Semantic proximity Read ↗

Impact of universal immunohistochemistry on Lynch syndrome diagnosis in an Australian colorectal cancer cohortSemantic proximity Read ↗

Yield of routine molecular analyses in colorectal cancer patients ≤70 years to detect underlying Lynch syndromeSemantic proximity Read ↗

Screening for Lynch syndrome in young Saudi colorectal cancer patients using microsatellite instability testing and next generation sequencing.Semantic proximity Read ↗

Comparison between universal molecular screening for Lynch syndrome and revised Bethesda guidelines in a large population-based cohort of patients with colorectal cancerSemantic proximity Read ↗

Screening for Lynch Syndrome in Young Colorectal Cancer Patients from Saudi Arabia Using Microsatellite Instability as the Initial Test.Semantic proximity Read ↗

Microsatellite Instability and Colorectal CancerSemantic proximity Read ↗

Lynch syndrome screening in colorectal cancer: results of a prospective 2-year regional programme validating the NICE diagnostics guidance pathway throughout a 5.2-million population.Semantic proximity Read ↗

Prevalence of Lynch syndrome in a Middle Eastern population with colorectal cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.