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A novel davunetide (NAPVSIPQ Q to NAPVSIPQ E ) point mutation in activity‐dependent neuroprotective protein (ADNP) causes a mild developmental syndrome

20 Jan 2023

Abstract excerpt

NAP (NAPVSIPQ, drug candidate name, davunetide) is the neuroprotective fragment of activity-dependent neuroprotective protein (ADNP). Recent studies identified NAPVSIP as a Src homology 3 (SH3) domain-ligand association site, responsible for controlling signalling pathways regulating the cytoskeleton. Furthermore, the SIP motif in NAP/ADNP was identified as crucial for direct microtubule end-binding protein...

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PMID: 36669790
DOI: 10.1111/ejn.15920

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