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Article

Acid-Responsive Dual-Targeted Nanoparticles Encapsulated Aspirin Rescue the Immune Activation and Phenotype in Autism Spectrum Disorder.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 May 2022

He Xueqin, Xie Jiang, Zhang Jing, Wang Xiaorong, Jia Xufeng, Yin Heng, Qiu Zhongqing, Yang Zhihang, Chen Jiao, Ji Zhiliang, Yu Wenqi, Chen Meiwan, Xu Wenming, Gao Huile

Abstract excerpt

The treatment of autism spectrum disorder (ASD) is one of the most difficult challenges in neurodevelopmental diseases, because of the unclear pathogenesis research and low brain-lesion targeting efficiency. Besides, maternal immune activation has been reported as the most mature and widely used model of ASD and aspirin-triggered lipoxin A4 is a potent anti-inflammatory mediator being involved in the resolution...

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PMID: 35285177
DOI: 10.1002/advs.202104286
PMCID: PMC9108608

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