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ADNP Plays a Key Role in Autophagy: From Autism to Schizophrenia and Alzheimer's Disease

21 Sept 2017

Abstract excerpt

Activity-dependent neuroprotective protein (ADNP), discovered in our laboratory in 1999, has been characterized as a master gene vital for mammalian brain formation. ADNP de novo mutations in humans result in a syndromic form of autism-like spectrum disorder (ASD), including cognitive and motor deficits, the ADNP syndrome (Helsmoortel-Van Der Aa). One of the most important cellular processes associated with ADNP...

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PMID: 28940660
DOI: 10.1002/bies.201700054

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