Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Risperidone and NAP protect cognition and normalize gene expression in a schizophrenia mouse model.

Scientific reports - 10 Nov 2015

Vaisburd Sinaya, Shemer Zeev, Yeheskel Adva, Giladi Eliezer, Gozes Illana

Abstract excerpt

Mutated disrupted in schizophrenia 1 (DISC1), a microtubule regulating protein, leads to schizophrenia and other psychiatric illnesses. It is hypothesized that microtubule stabilization may provide neuroprotection in schizophrenia. The NAP (NAPVSIPQ) sequence of activity-dependent neuroprotective protein (ADNP) contains the SxIP motif, microtubule end binding (EB) protein target, which is critical for microtubule...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cognition
Share to Doxycycline
Share to Hippocampus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microtubule-Associated Proteins

Share to Molecular Dynamics Simulation

Share to Neuroprotective Agents

Share to Oligopeptides

Share to Risperidone

Source

Open in PubMed Open full text

Identifiers

PMID: 26553741
DOI: 10.1038/srep16300
PMCID: PMC4639790

Genes

DISC1
ADNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Risperidone and NAP protect cognition and normalize gene expression in a schizophrenia mouse model.PMID 26553741Read ↗

New horizons in schizophrenia treatment: autophagy protection is coupled with behavioral improvements in a mouse model of schizophreniaSemantic proximity Read ↗

Using mouse transgenic and human stem cell technologies to model genetic mutations associated with schizophrenia and autism.Semantic proximity Read ↗

ADNP Plays a Key Role in Autophagy: From Autism to Schizophrenia and Alzheimer's DiseaseSemantic proximity Read ↗

The autism/neuroprotection-linked ADNP/NAP regulate the excitatory glutamatergic synapseSemantic proximity Read ↗

Activity-dependent neuroprotective protein (ADNP): a case study for highly conserved chordata-specific genes shaping the brain and mutated in cancer.Semantic proximity Read ↗

Disrupted-In-Schizophrenia-1 (DISC1) interactome and mental disorders: Impact of mouse modelsSemantic proximity Read ↗

Disrupted in schizophrenia 1: building brains and memories.Semantic proximity Read ↗

Activity-dependent neuroprotective protein (ADNP) exhibits striking sexual dichotomy impacting on autistic and Alzheimer’s pathologiesSemantic proximity Read ↗

Activity-dependent neuroprotective protein deficiency models synaptic and developmental phenotypes of autism-like syndrome.Semantic proximity Read ↗

Genetic and Environmental Factors Co-Contributing to Behavioral Abnormalities in adnp/adnp2 Mutant Zebrafish.Semantic proximity Read ↗

A behavioral screen for mediators of age-dependent TDP-43 neurodegeneration identifies SF2/SRSF1 among a group of potent suppressors in both neurons and gliaSemantic proximity Read ↗

Disrupted-in-Schizophrenia-1 (DISC-1): Mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowthSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.