Elevated H3K27me3 levels sensitize osteosarcoma to cisplatin

Abstract excerpt

BACKGROUND: In osteosarcoma (OS), chemotherapy resistance has become one of the greatest issues leading to high mortality among patients. However, the mechanisms of drug resistance remain elusive, limiting therapeutic efficacy. Here, we set out to explore the relationship between dynamic histone changes and the efficacy of cisplatin against OS. RESULTS: First, we found two histone demethylases associated with...

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