Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GTSE1 is possibly involved in the DNA damage repair and cisplatin resistance in osteosarcoma

1 Dec 2021

Abstract excerpt

BACKGROUND: G2 and S phase-expressed-1 (GTSE1) negatively regulates the tumor-suppressive protein p53 and is potentially correlated with chemoresistance of cancer cells. This study aims to explore the effect of GTSE1 on the DNA damage repair and cisplatin (CDDP) resistance in osteosarcoma (OS). MATERIALS AND METHODS: Expression of GTSE1 in OS was predicted in bioinformatics system GEPIA and then validated in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Erythrocyte Function and Pathophysiology
Share to Ion Transport and Channel Regulation
Share to PI3K/AKT/mTOR signaling in cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34876170
DOI: 10.1186/s13018-021-02859-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GTSE1 is possibly involved in the DNA damage repair and cisplatin resistance in osteosarcomaPMID 34876170Read ↗

GTSE1 is involved in breast cancer progression in p53 mutation-dependent mannerSemantic proximity Read ↗

The Cell Cycle-regulated Protein Human GTSE-1 Controls DNA Damage-induced Apoptosis by Affecting p53 FunctionSemantic proximity Read ↗

High GTSE1 expression promotes cell proliferation, metastasis and cisplatin resistance in ccRCC and is associated with immune infiltrates and poor prognosisSemantic proximity Read ↗

GTSE1 Facilitates the Malignant Phenotype of Lung Cancer Cells via Activating AKT/mTOR Signaling.Semantic proximity Read ↗

High GTSE1 expression promotes cell proliferation, metastasis and cisplatin resistance in ccRCC and is associated with immune infiltrates and poor prognosisSemantic proximity Read ↗

FoxG1/BNIP3 axis promotes mitophagy and blunts cisplatin resistance in osteosarcomaSemantic proximity Read ↗

GTSE1, CDC20, PCNA, and MCM6 Synergistically Affect Regulations in Cell Cycle and Indicate Poor Prognosis in Liver CancerSemantic proximity Read ↗

Pharmacogenomic Profiling of Cisplatin-Resistant and -Sensitive Human Osteosarcoma Cell Lines by Multimodal Targeted Next Generation Sequencing.Semantic proximity Read ↗

PRKDC Induces Chemoresistance in Osteosarcoma by Recruiting GDE2 to Stabilize GNAS and Activate AKTSemantic proximity Read ↗

Elevated H3K27me3 levels sensitize osteosarcoma to cisplatinSemantic proximity Read ↗

Stabilization of GTSE1 by cyclin D1-CDK4/6-mediated phosphorylation promotes cell proliferation: relevance in cancer prognosisSemantic proximity Read ↗

Stabilization of GTSE1 by cyclin D1–CDK4/6-mediated phosphorylation promotes cell proliferation with implications for cancer prognosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.