Understanding Heterogeneity in Biologic Phenotypes of Acute Respiratory Distress Syndrome by Leukocyte Expression Profiles

Abstract excerpt

Abstract Rationale Two biologic phenotypes of acute respiratory distress syndrome (ARDS) have been identified based on plasma protein markers in four previous studies. Objectives To determine if blood leukocyte gene expression is different between the “reactive” and “uninflamed” phenotype. Methods This is a new study adding blood leukocyte transcriptomics and bioinformatics analysis to an existing patient cohort...

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