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Article

Genetic and Nongenetic Risk Factors for Breast Cancer Risk Estimation.

JAMA network open - 1 Apr 2025

Guo Wenji, Li James L, McClellan Julian, Ntekim Atara, Ojengbede Oladosu, Ogundiran Temidayo, Odetunde Abayomi, Obafunwa John, Popoola Abiodun, Ndom Paul, Gakwaya Antony, Chatterjee Nilanjan, Sveen Elisabeth, Yoshimatsu Toshio F, Zheng Yonglan, Olopade Olufunmilayo I, Huo Dezheng

Abstract excerpt

Importance: Most breast cancers in Africa are diagnosed at advanced stages. Improved risk prediction tools to optimize screening and earlier diagnosis are urgently needed. Objective: To build a comprehensive breast cancer risk estimation model by integrating a polygenic risk score (PRS), pathogenic variants (PVs) in high- or moderate-penetrance genes, and a questionnaire-based risk calculator. Design, Setting,...

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Source

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Identifiers

PMID: 40249615
DOI: 10.1001/jamanetworkopen.2025.5804
PMCID: PMC12008756

Genes

ATM
BARD1
BRCA1
BRCA2
CHEK2
PALB2
RAD51C
RAD51D
TP53

Provenance

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