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LUBAC determines chemotherapy resistance in squamous cell lung cancer

14 Jan 2019

Abstract excerpt

Lung squamous cell carcinoma (LSCC) and adenocarcinoma (LADC) are the most common lung cancer subtypes. Molecular targeted treatments have improved LADC patient survival but are largely ineffective in LSCC. The tumor suppressor FBW7 is commonly mutated or down-regulated in human LSCC, and oncogenic KRasG12D activation combined with Fbxw7 inactivation in mice (KF model) caused both LSCC and LADC. Lineage-tracing...

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PMID: 30642944
DOI: 10.1084/jem.20180742

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