Article
CUL4B functions as a tumor suppressor in KRAS-driven lung tumors by inhibiting the recruitment of myeloid-derived suppressor cells.
Oncogene - 1 Oct 2023
Liu Xiaochen, Tian Fei, Cui Jianfeng, Gong Li, Xiang Lu, Fan Bowen, Liu Shuangteng, Zhan Jiafeng, Zhou Yadi, Jiang Baichun, Wang Molin, Sun Gongping, Gong Yaoqin, Zou Yongxin
Abstract excerpt
Lung cancer is the leading cause of cancer-related death worldwide. KRAS mutations are the most common oncogenic alterations found in lung cancer. Unfortunately, treating KRAS-mutant lung adenocarcinoma (ADC) remains a major oncotherapeutic challenge. Here, we used both autochthonous and transplantable KRAS-mutant tumor models to investigate the role of tumor-derived CUL4B in KRAS-driven lung cancers. We showed...
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