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Article

Single-cell genomics illustrates heterogeneous phenotypes of myocardial fibroblasts under ischemic insults.

Biochemistry and cell biology = Biochimie et biologie cellulaire - 1 Feb 2023

Thankam Finosh G, La Vy, Agrawal Devendra K

Abstract excerpt

Myocardial regenerative strategies are promising where the choice of ideal cell population is crucial for successful translational applications. Herein, we explored the regenerative/repair responses of infarct zone cardiac fibroblast(s) (CF) by unveiling their phenotype heterogeneity at single-cell resolution. CF were isolated from the infarct zone of Yucatan miniswine that suffered myocardial infarction,...

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PMID: 36458696
DOI: 10.1139/bcb-2022-0229

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