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Article

HOXA5 Counteracts Stem Cell Traits by Inhibiting Wnt Signaling in Colorectal Cancer.

Cancer cell - 14 Dec 2015

Ordóñez-Morán Paloma, Dafflon Caroline, Imajo Masamichi, Nishida Eisuke, Huelsken Joerg

Abstract excerpt

Hierarchical organization of tissues relies on stem cells, which either self-renew or produce committed progenitors predestined for lineage differentiation. Here we identify HOXA5 as an important repressor of intestinal stem cell fate in vivo and identify a reciprocal feedback between HOXA5 and Wnt signaling. HOXA5 is suppressed by the Wnt pathway to maintain stemness and becomes active only outside the...

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Identifiers

PMID: 26678341
DOI: 10.1016/j.ccell.2015.11.001

Genes

HOXA5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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