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Rescue axonal defects by targeting mitochondrial dynamics in hereditary spastic paraplegias

10 Jan 2019

Abstract excerpt

Impaired axonal development and degeneration underlie debilitating neurodegenerative diseases including hereditary spastic paraplegia, a large group of inherited diseases. Hereditary spastic paraplegia is caused by retrograde degeneration of the long corticospinal tract axons, leading to progressive spasticity and weakness of leg and hip muscles. There are over 70 subtypes with various underlying...

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Share to Cerebral Palsy and Movement Disorders
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PMID: 30632492
DOI: 10.4103/1673-5374.248108

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